METABOLISM OF RESISTANT MUTANTS OF STREPTOCOCCUS FAECALIS IV

Metabolism of resistant mutants of Streptococcus faecalis. I. Isolation and characterization of the mutants.

The currently unavoidable phenomenon of the appearance of drug-refractory leukemic cells in children whose disease was at one time responsive to that drug has served as a stimulus for the study of strains of microorganisms resistant to such agents. A series of mutants of Streptococcusfaecalis has been selected, and these mutants exhibit vari ous degrees of resistance to A-methopterin, 6-mercapt...

Metabolism of resistant mutants of Streptococcus faecalis. III. The action of 6-mercaptopurine.

The compound 6-mercaptopurine (6-MP) has been shown to possess definite antitumor (13) properties and to inhibit the growth of several microorganisms (14-16). This inhibition has been reversed by several purines (14-16), and it is possible that the antitumor action is also con cerned with purine metabolism. The present exper iments were undertaken in an attempt to elucidate the action of 6-MP b...

Hydroxylysine metabolism in Streptococcus faecalis.

Anaerobic Endogenous Metabolism in Streptococcus Faecalis.

Walker, D. J. (CSIRO, University of Adelaide, Adelaide, South Australia), and W. W. Forrest. Endogenous metabolism in Streptococcus faecalis. J. Bacteriol. 87:256-262. 1964.-Washed suspensions of Streptococcus faecalis incubated in phosphate buffer (pH 6.0) under anaerobic conditions released amino acids into the suspending medium. Little or no carbohydrate was released in soluble form, and no ...

Phospholipids of Streptococcus faecalis.

Autoradiograms of total lipid extracts from Streptococcus faecalis ATCC 9790, harvested in the stationary phase from a medium containing (32)P-orthophosphate, showed six major spots. The corresponding compounds were identified as diphosphatidylglycerol (possibly with a penta acyl structure); phosphatidylglycerol; a provisionally identified mixture of alanylphosphatidylglycerol and of the 2'-lys...